Cenforce®

Cenforce Cenforce

The product Cenforce® is a complete analog of the famous product Viagra® made by Pfizer. The only difference is the possible content of the amount of active substance and the price. A more affordable Indian brand made by Centurion Laboratories to increase potency, in addition to standard dosages, is available in the increased dosages of Sildenafil, such as 120 mg, 150 mg, 200 mg, which greatly enhances the chances of success. Indeed, many men who negatively spoke about Viagra®, after taking Cenforce® 150, for example, changed their attitude to Sildenafil.

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  • Brand(s):Cenforce
  • Manufacturer:Centurion Laboratories Ltd.
  • Disease(s):Erectile Dysfunction / Impotence / Pulmonary Arterial Hypertension
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Cenforce 100

What is the difference between Cenforce 100 mg and Sildenafil?

Excipients: cellulose microcrystalline calcium phosphate; aluminum hydroxide sodium croscarmellose; povidone, magnesium stearate silicon dioxide colloidal dry mixture “Opadry II white” containing titanium dioxide (E 171), talc, polyethylene glycol (macrogol), polyvinyl alcohol; Indigo (E 132) kandurin “Silver luster”.
Dosage form

Cenforce 100 mg contraindications

The main physical and chemical properties: tablets, coated, from blue to blue with a pearl shade of round shape, with a biconvex surface. Marbling is allowed.
Pharmacological group

Means used in erectile dysfunction. Cenforce 100. ATC code G04B E03.
Pharmacological properties

Cenforce 100 mg side effects

Mechanism of action. Cenforce 100 is a drug for oral administration, intended for the treatment of erectile dysfunction. With sexual arousal, the drug restores reduced erectile function by increasing blood flow to the penis.

Physiological mechanism that leads to erection, including the release of nitric oxide (NO) in cavernous bodies during sexual arousal. The released nitric oxide activates the enzyme guanylate cyclase, which stimulates an increase in the level of cyclic guanosine monophosphate (cGMP), which in turn causes relaxation of the smooth muscles of the cavernous bodies, contributing to blood flow.

How to take Cenforce 100 mg

Cenforce 100 is a potent selective inhibitor of cGMP-specific phosphodiesterase 5 (PDE-5) in cavernous bodies, where PDE-5 is responsible for the breakdown of cGMP. The effect of Cenforce 100 on erection is peripheral. Cenforce 100 does not have a direct relaxing effect on isolated cavernous human bodies, but powerfully enhances the relaxing effect of NO on this tissue. With the activation of the metabolic pathway of NO / cGMP, which occurs during sexual stimulation, inhibition by Cenforce 100 PDE5 leads to an increase in the level of cGMP in the cavernous bodies. Thus, in order for Cenforce 100 to cause a pharmacological effect, sexual arousal is necessary.

Why Cenforce 100 mg is a popular treatment for erectile dysfunction problems

Influence on pharmacodynamics. Cenforce 100 is selective to PDE-5, which is actively involved in the erection process. The effect of Cenforce 100 on PDE-5 is more powerful than on other known phosphodiesterases, in particular 10 times more powerful than the effect on PDE6, involved in the processes of photoregulation in the retina. When using the maximum recommended doses of selectivity of Cenforce 100 in PDE-5 to 80 times greater than its selectivity for ФДЕ1, 700 times higher than in ФДЕ2, PDAS, ФДЕ4, ФДЕ7, ФДЕ8, ФДЕ9, ФДЕ10 and ФДЕ11. In particular, selectivity of Cenforce 100 in PDE-5 is 4000 times higher than its selectivity to FDEZ – camp-specific PDE isoform involved in regulation of cardiac contractility.

Who can use Cenforce 100 mg?

Absorption. Cenforce 100 is rapidly absorbed. Maximum plasma concentrations are reached within 30 to 120 minutes (median 60 minutes) after oral administration on an empty stomach. The average bioavailability after oral administration is 41% (with a range of values from 25 to 63%). In the recommended dose range (from 25 to 100 mg) and AUC with max Cenforce 100 after oral administration increases in proportion to the dose.

In the application of Cenforce 100 during meals extent of absorption is reduced, with an average lengthening of the T max of 60 minutes and an average reduction in C max of 29%.

Distribution. The average equilibrium volume of distribution (V d ) is 105 liters, which indicates the distribution of the drug in the tissues of the body. After a single oral administration of Cenforce 100 at a dose of 100 mg, the average maximum total plasma concentration of Cenforce 100 is approximately 440 ng / ml (coefficient of variation is 40%). Since the binding of Cenforce 100 and its main N-desmethyl metabolite to plasma proteins reaches 96%, the average maximum plasma concentration of free Cenforce 100 reaches 18 ng / ml (38 nmol). The degree of binding to plasma proteins does not depend on the total concentration of Cenforce 100.

How Cenforce 100 mg treats erectile dysfunction problems

In individuals, taking Cenforce 100 once in a dose of 100 mg, after 90 minutes in the ejaculate was determined less than 0.0002% (average 188 ng) dose.

Metabolism. The metabolism of Cenforce 100 is mainly carried out with the participation of microsomal liver isoenzymes CYP3A4 (main pathway) and CYP2C9 (secondary pathway). The main circulating metabolite is formed by N-demethylation of Cenforce 100. The selectivity of the metabolite relative to PDE-5 is comparable to the selectivity of Cenforce 100, and the activity of the metabolite relative to PDE-5 is approximately 50% of the activity of the starting substance. The plasma concentration of this metabolite is approximately 40% of the concentration of Cenforce 100 in plasma. The N-demethylated metabolite is further metabolized, and t ? is approximately 4: 00.

What do I need to know about Cenforce 100?

Breeding. The total clearance of Cenforce 100 is 41 l / h, causing t ? about 3-5: 00. Both after administration and after administration, the excretion of Cenforce 100 in the form of metabolites is carried out mainly with feces (approximately 80% of the administered oral dose) and to a lesser extent with urine (approximately 13% of the administered oral dose).

Pharmacokinetics in special groups of patients.

Elderly patients. In the elderly (over 65 years) there was a decrease in the clearance of Cenforce 100, which led to an increase in the plasma concentration of Cenforce 100 and its active n-demethylated metabolite by about 90% compared with the corresponding concentrations in young people (18-45 years). Due to age differences in plasma protein binding, the corresponding increase in the plasma concentration of free Cenforce 100 was approximately 40%.

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Renal failure. In patients with impaired renal function or moderate (creatinine clearance 30 – 80 ml / min) the pharmacokinetics of Cenforce 100 was unchanged after a single oral dose of 50 mg. Average AUC and C max of the N-demethylated metabolite increased 126% and 73% respectively in comparison with these indicators in individuals of the same age without renal impairment. However, due to high individual variability, these differences were not statistically significant. In individuals with severe renal impairment (creatinine clearance less than 30 ml / min), Cenforce 100 clearance decreased, leading to average increases in AUC and C max by 100% and 88%, respectively, compared with individuals of the same age without renal impairment. In addition, the value of AUC and C max N-demethylated metabolite significantly increased by 200% and 79%, respectively.

Liver failure. In persons with mild to moderate cirrhosis (class a and b according to child-Pugh classification), Cenforce 100 clearance decreased, which led to an increase in AUC (84%) and C max (47%) compared to persons of the same age without liver dysfunction. Pharmacokinetics of Cenforce 100 in patients with severe hepatic impairment has not been studied.
indications

To use Cenforce 100

The drug is recommended for men with erectile dysfunction, which is defined as the inability to achieve or maintain the erection of the penis necessary for successful sexual intercourse.

For the effective action of the drug, sexual arousal is necessary.

Cenforce
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